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You are considering testing a new drug that is supposed to facilitate learning in developmentally delayed children

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You are considering testing a new drug that is supposed to facilitate learning in developmentally delayed children. Based on preliminary research, you have some idea about the size of the drug's effect. Because of your work schedule you can either do the test with 15 subjects or with 20. You would like to only run 15 subjects, but if running 20 will make power at least 20% higher, you will run 20 subjects.  

Calculate power for the following conditions:

 a.N = 15, a = .051 tailPreal = 0.70. b.N = 20, a = .051 tailPreal = 0.70. c.Based on your calculations, how many subjects will you test?   

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H0?:p?=0.5H1?:p?>0.5significancelevel,α=0.05?

 

a.

N = 15, a = .05 1 tail, P real = 0.70

 

standard deviation =??15(0.5)(1−0.5)??? = 0.1291

critical z value for 95% confidence = 1.6449

critical = 0.5 + 1.6449 * 0.1291= 0.7124

 

z assuming null hypothesis is false:

z =?????0.12910.7124−0.7??? = 0.0960

 

power = P(z > 0.0960) = 0.46176

 

b.

N = 20, a = .05 1 tail, Preal = 0.70. 

 

standard deviation =???20(0.5)(1−0.5)????? = 0.1118

critical z value for 95% confidence = 1.6449

critical = 0.5 + 1.6449 * 0.1118= 0.6839

 

z assuming null hypothesis is false:

z =???????0.11180.6839−0.7????? = -0.1440

 

power = P(z > -0.1440) = 0.55725

 

c.

percentage increase in power = ?0.461760.55725−0.46176?? *100 = 20.6795 %

 

since the percentage increase in power is greater than 20%, we should go with 20 samples