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Homework answers / question archive / x BU MPP #2 Instructions - Spring 2 x + c

x BU MPP #2 Instructions - Spring 2 x + c

Sociology

x BU MPP #2 Instructions - Spring 2 x + c.edu/webapps/blackboard/execute/content/file?cmd=view&content_id=_778966_1&course_id=219837 110% 0 Assignment # 2: Description: Look up the chemical structure (structural formula) of your drug in The Merck Index (14th ed.) online through the library database Instructions are listed in the MPP folder on Blackboard on how to access the database O . If your drug is a derivative, check with the instructor for the necessary modifications. Make sure to reference the Molecule Portfolio Project overview document as well as the video O O The Merck Index, only lists the parent compound. If you have a derivative of the parent compound, the instructor will need to modify the compound. Only then you need to see me. Plan ahead, in order to have time to meet with me and submit your assignment on time. Make sure to be able to reference the database often for the remainder of the assignments. Complete the cover page (p.1) of your portfolio, showing the hand- drawn structural formula of your drug, its generic name and the trade name you were assigned. Neatness will be part of the grading of all assignments. You may copy and paste the image of your drug if using the Merck Online Database through the library O o E d Bb MPP #4 Instructions - Spring 2 x + webapps/blackboard/execute/content/file?cmd=view&content_id=_779007_1&course_id=_19837 110% ... 1 of 1 - + Automatic Zoom Assignment # 4: On a page titled Solution Calculations show the steps and answers for the two solution problems listed below. Also describe in a technical procedure how to mix the resulting solution in part a. Be sure to check significant figures in your final answer. To help you with this assignment, refer to the examples in Chapter 9. Work neatly and use complete sentences for the solution preparation process. d. Calculate the number of grams of drug to be weighed to prepare 550.0 mL of a 2.50 x 10-3 M solution from your pure drug and water. .(Hint: you will need the molar mass of your drug calculated in MPP #3) b. Describe (1-2 sentences) how this solution would be made as if you were instructing someone how to make it in a laboratory procedure. (Hint: See page 11 in Chapter 9 Notes) c. Calculate how many milligrams of your drug are in 350.0 mL of a 7.25 % (m/v) solution. (Hint: Solve this problem. The molar mass of your drug is not needed- you can solve for grams using the numbers given. You will need the conversion factor of 1000 mg= 18 ) — + 80% Assignment #5 1. Identify the functional groups in the drug molecule. On a page titled Functional Groups draw/print the structural formula of your drug (expanded or condensed) and indicate the functional groups present by highlighting, circling or color-coding each and labeling the group. You are only responsible for groups that are in the Organic Packet, and in Chapter 10 in your textbook. 2. Identify all chiral carbons in the drug molecule. On a page titled Chiral Carbons print/draw the expanded structure of your drug. Determine if your molecule contains any chiral carbons. If there are chiral carbons in your drug, circle or highlight all of them. If your drug does not contain any chiral carbons explain why none of the carbons are chiral. Calculate the maximum number of possible stereoisomers of your drug using the following formula: Maximum number of possible stereoisomers = 2" (where n= the number of chiral carbons in your molecule). Example: if a molecule has 3 chiral carbons the maximum possible number of stereoisomers it could have would be 23 = 8. 3. Illustrate how the drug can form hydrogen bonds with water. On a page titled Hydrogen Bonding with Water print or draw the expanded structure of your drug. If the structure of your drug already contains any dashed lines, make them solid (non- dashed) covalent bonds for this assignment so that they are not confused with the hydrogen bonds Illustrate all the locations where your molecule could form hydrogen bonds with water, either as a hydrogen donor or as an acceptor of hydrogen bonds from water. Do this by drawing bent water molecules as necessary and representing hydrogen bonds between water and the drug using dashed lines. Be sure it is very clear exactly which atoms on each molecule are involved in the hydrogen bonds. Donor One example hydrogen bond is illustrated here where the molecule is a receiver of hydrogen bonding from water at the oxygen doubly bonded to carbon. H H- Accepter If your drug molecule is not capable of forming hydrogen bonds with water, explain why not. H- CH Polarity and Solubility Predictions. On a page titled Polarity and Solubility Predictions draw/print the structural formula of your drug (expanded or condensed). a. Circle or highlight all polar portions of the molecule. b. Make predictions whether your molecule will be soluble in water or not, and explain rationale. Compare your predictions with any water-solubility information discussed in The Merck Index. Discuss potential noncovalent attractions between the drug and amino acid side groups in a protein." Many drugs work by binding to proteins such as enzymes or protein receptors. Understanding how a drug binds to such molecules sheds light on how it works and can help in designing similar drugs. This binding involves noncovalent attractions between the protein and the drug molecule: 1. Protein Binding - Hydrophobic Interactions 2. Protein Binding – Hydrogen Bonding 3. Protein Binding – Ionic Attractions 1. Hydrophobic Interactions. This means identifying major nonpolar regions of the drug that will be involved in binding to nonpolar regions of the protein. On a page titled Protein Binding - Hydrophobic Interactions print/draw the structural formula of your drug (expanded or condensed). Highlight any regions of your drug that are nonpolar and thus could be involved in such interactions. O=0 CH3 CH2 CH2 CH 1 CH CH NEC OH Nonpolar (hydrophobic) regions CH2 Recall the following bonds of carbon with corresponding atoms are polar: C-O, C-N, C-Cl, C-F BL MPP #3 Instructions - Spring 2 X 3 + u/webapps/blackboard/execute/content/file?cmd=view&content_id=_778983_1&course_id=_19837 110% D Assignment # 3: 1. On the page titled: Expanded Structural Formula Draw the expanded structure of your drug. Show every atom and every covalent bond in the molecule. For every nonmetal atom that is not carbon or hydrogen, add electron pairs as needed so that this atom has eight valence electrons. 2. On the page titled: Molar Mass Calculation Use the expanded structure to determine The molecular formula (can be found from the Merck Index database) The molar mass. Use atomic masses from the periodic table to the hundredth place for each element. C x BU MPP #2 Instructions - Spring 2 x + c.edu/webapps/blackboard/execute/content/file?cmd=view&content_id=_778966_1&course_id=219837 110% 0 Assignment # 2: Description: Look up the chemical structure (structural formula) of your drug in The Merck Index (14th ed.) online through the library database Instructions are listed in the MPP folder on Blackboard on how to access the database O . If your drug is a derivative, check with the instructor for the necessary modifications. Make sure to reference the Molecule Portfolio Project overview document as well as the video O O The Merck Index, only lists the parent compound. If you have a derivative of the parent compound, the instructor will need to modify the compound. Only then you need to see me. Plan ahead, in order to have time to meet with me and submit your assignment on time. Make sure to be able to reference the database often for the remainder of the assignments. Complete the cover page (p.1) of your portfolio, showing the hand- drawn structural formula of your drug, its generic name and the trade name you were assigned. Neatness will be part of the grading of all assignments. You may copy and paste the image of your drug if using the Merck Online Database through the library O o E d BL MPP #3 Instructions - Spring 2 X 3 + u/webapps/blackboard/execute/content/file?cmd=view&content_id=_778983_1&course_id=_19837 110% D Assignment # 3: 1. On the page titled: Expanded Structural Formula Draw the expanded structure of your drug. Show every atom and every covalent bond in the molecule. For every nonmetal atom that is not carbon or hydrogen, add electron pairs as needed so that this atom has eight valence electrons. 2. On the page titled: Molar Mass Calculation Use the expanded structure to determine The molecular formula (can be found from the Merck Index database) The molar mass. Use atomic masses from the periodic table to the hundredth place for each element. C Bb MPP #4 Instructions - Spring 2 X + webapps/blackboard/execute/content/file?cmd=view&content_id=_779007_1&course_id=_19837 110% ... 1 of 1 - + Automatic Zoom Assignment # 4: On a page titled Solution Calculations show the steps and answers for the two solution problems listed below. Also describe in a technical procedure how to mix the resulting solution in part a. Be sure to check significant figures in your final answer. To help you with this assignment, refer to the examples in Chapter 9. Work neatly and use complete sentences for the solution preparation process. d. Calculate the number of grams of drug to be weighed to prepare 550.0 mL of a 2.50 x 10-3 M solution from your pure drug and water. .(Hint: you will need the molar mass of your drug calculated in MPP #3) b. Describe (1-2 sentences) how this solution would be made as if you were instructing someone how to make it in a laboratory procedure. (Hint: See page 11 in Chapter 9 Notes) C. Calculate how many milligrams of your drug are in 350.0 mL of a 7.25 % (m/v) solution. (Hint: Solve this problem. The molar mass of your drug is not needed- you can solve for grams using the numbers given. You will need the conversion factor of 1000 mg= 18 ) - + 80% Assignment #5 1. Identify the functional groups in the drug molecule. On a page titled Functional Groups draw/print the structural formula of your drug (expanded or condensed) and indicate the functional groups present by highlighting, circling or color-coding each and labeling the group. You are only responsible for groups that are in the Organic Packet, and in Chapter 10 in your textbook. 2. Identify all chiral carbons in the drug molecule. On a page titled Chiral Carbons print/draw the expanded structure of your drug. Determine if your molecule contains any chiral carbons. If there are chiral carbons in your drug, circle or highlight all of them. If your drug does not contain any chiral carbons explain why none of the carbons are chiral. Calculate the maximum number of possible stereoisomers of your drug using the following formula: Maximum number of possible stereoisomers = 2" (where n= the number of chiral carbons in your molecule). Example: if a molecule has 3 chiral carbons the maximum possible number of stereoisomers it could have would be 23 = 8. 3. Illustrate how the drug can form hydrogen bonds with water. On a page titled Hydrogen Bonding with Water print or draw the expanded structure of your drug. If the structure of your drug already contains any dashed lines, make them solid (non- dashed) covalent bonds for this assignment so that they are not confused with the hydrogen bonds Illustrate all the locations where your molecule could form hydrogen bonds with water, either as a hydrogen donor or as an acceptor of hydrogen bonds from water. Do this by drawing bent water molecules as necessary and representing hydrogen bonds between water and the drug using dashed lines. Be sure it is very clear exactly which atoms on each molecule are involved in the hydrogen bonds. Donor One example hydrogen bond is illustrated here where the molecule is a receiver of hydrogen bonding from water at the oxygen doubly bonded to carbon. H H- Accepter If your drug molecule is not capable of forming hydrogen bonds with water, explain why not. H- CH Polarity and Solubility Predictions. On a page titled Polarity and Solubility Predictions draw/print the structural formula of your drug (expanded or condensed). a. Circle or highlight all polar portions of the molecule. b. Make predictions whether your molecule will be soluble in water or not, and explain rationale. Compare your predictions with any water-solubility information discussed in The Merck Index. Discuss potential noncovalent attractions between the drug and amino acid side groups in a protein." Many drugs work by binding to proteins such as enzymes or protein receptors. Understanding how a drug binds to such molecules sheds light on how it works and can help in designing similar drugs. This binding involves noncovalent attractions between the protein and the drug molecule: 1. Protein Binding - Hydrophobic Interactions 2. Protein Binding – Hydrogen Bonding 3. Protein Binding – Ionic Attractions 1. Hydrophobic Interactions. This means identifying major nonpolar regions of the drug that will be involved in binding to nonpolar regions of the protein. On a page titled Protein Binding - Hydrophobic Interactions print/draw the structural formula of your drug (expanded or condensed). Highlight any regions of your drug that are nonpolar and thus could be involved in such interactions. O=0 CH3 CH2 CH2 CH 1 CH CH NEC OH Nonpolar (hydrophobic) regions CH2 Recall the following bonds of carbon with corresponding atoms are polar: C-O, C-N, C-Cl, C-F Assignment #7: Final Paper (worth 45 points) The one page report should be a written summary of all assignments and should be a representation of how well you can write in a technical way about your molecule. While other interesting or personal information can improve the overall flow of the report, it should not be primarily about that extraneous information. Additional information about the drug that can be included in the report is listed below. At least two of the four topics should be included in some way. If you use any information that is not yours, you must cite it. You may use any reference format (MLA, ACS, etc.). Coping and pasting a website is not considered a proper citation. Additional Drug Information 1. Mechanism of action (for example: how it binds to biological molecules, how it may inhibit enzyme activity). 2. Dosage, packaging 3. Side effects 4. Historical information of interest. Please do not copy and paste directly from the internet. Please remember to cite your sources for your information. You should avoid using quotes. Make sure the information is in your own words. You will need to submit along with your paper: a cover page (can be reused from Assignment #2 if no corrections are needed) o Should include the condensed structure of your drug, Generic and Trade name of drug • All assignments (2 (cover page only), 3, 4, 5, 6) with any corrections made and uploaded in order The following is the grading rubric for your presentation. 1. One page report 2. All corrections made 3. All items are assignments are included in report 4. Sources properly cited /20 /15 /5 /5 Total__/45 Assignments: Condensed/expanded structural formulas, molecular formula, molar mass, solution calculations, functional groups, chiral carbons, hydrogen bonding with water, polarity of molecule, nonpolar regions of the molecule, hydrogen bonding with amino acid, and ionic attractions. Submit via blackboard by 12/14 midnight

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