University of Illinois, Chicago

NURS 531

Chapter 14: Noradrenergic transmission

MULTIPLE CHOICE

1)An intravenous infusion of norepinephrine typically

1. increases peripheral resistance and heart rate
2. decreases peripheral resistance and heart rate
3. increases peripheral resistance and decreases heart rate
4. decreases peripheral resistance and increases heart rate
5. has no consistent effect on peripheral resistance and heart rate

2.    In the liver, epinephrine acts via adrenergic beta-2 receptors to

1. stimulate both phosphorylase and glycogen synthase
2. inhibit both phosphorylase and glycogen synthase
3. inhibit phosphorylase and stimulate glycogen synthase
4. stimulate phosphorylase and inhibit glycogen synthase
5. stimulate phosphorylase, glycogen synthase, and lipase

3.    Which drug inhibits the transport of norepinephrine into synaptic vesicles, thereby leading to neurotransmitter depletion?

1. reserpine
2. methyldopa
3. bretylium
4. 6-hydroxydopamine
5. guanethidine

4.    Doxazosin is an example of a

1. nonselective alpha-adrenoceptor antagonist
2. selective alpha-1 adrenoceptor antagonist
3. selective alpha-2 adrenoceptor antagonist
4. selective alpha-1 adrenoceptor agonist
5. selective alpha-2 adrenoceptor agonist

5.    Irreversible blockade of alpha-adrenoceptors results from covalent binding of these receptors by

1. phentolamine
2. phenylephrine
3. prazosin
4. phenoxybenzamine
5. pseudoephedrine

6.    The reuptake of norepinephrine by presynaptic nerve terminals (uptake 1) is inhibited by

1. guanethidine
2. reserpine
3. methyldopa

4. methyltyrosine
5. cocaine

7.    The first-line treatment for acute severe type I hypersensitivity reactions is

1. dopamine
2. epinephrine
3. isoproterenol
4. norepinephrine
5. phenylephrine

8.    Which adrenergic receptor antagonist increases heart rate at rest but reduces it during exercise?

1. pindolol
2. propranolol
3. prazosin
4. timolol
5. phentolamine

9.    In the peripheral tissues, the primary end product of norepinephrine metabolism is

1. 3-methoxy, 4-hydroxyphenylglycol
2. normetanephrine
3. vanillylmandelic acid
4. 3,4-dihydroxymandelic acid
5. 3,4-dihydroxyphenylglycol

10.   The adverse effects of beta-adrenoceptor antagonists include

1. hyperglycemia
2. cardiac arrhythmias
3. myocardial ischemia
4. anxiety
5. bronchoconstriction

11.   Selective beta-3 adrenoceptor agonists are potentially useful in treating obesity because of their ability to

1. suppress appetite
2. inhibit digestion of fats
3. uncouple oxidative phosphorylation
4. increase thermogenesis
5. increase thyroid function

12.   Symptoms of urinary retention due to benign prostatic hyperplasia may be improved by