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Florida A&M University PHARMACY PHA 3102 Quiz 3 1)Bioavailability data are used to determine all of the following except:   a

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Florida A&M University

PHARMACY PHA 3102

Quiz 3

1)Bioavailability data are used to determine all of the following except:

 

a.            The relationship between drug blood levels and clinical efficacy and toxicity

 

b.            The amount or proportion of drug absorbed from the dosage form

 

c.             The duration of the drug’s presence in the biologic fluid or tissue correlated with the patient’s response

 

d.            The palatability of a drug in different dosage

 

e.            The rate at which the drug is absorbed

 

2.            Which of the following are factors that a pharmacist must consider when determining a dosage regimen for a specific patient? (Select all that apply)

a.            Pharmacodynamics and toxicity of the drug

 

b.            Clinical state of the patient

 

c.             Pharmacokinetics of the drug

 

d.            How the patient will be managed

3.            Reconstituted ampicillin suspension is stable for 16 days (shelf­life) when stored in the

refrigerator (5°C). If the product is left at room temperature (25°C), what is the reduction in the expiration dating?

4.            An ophthalmic solution has a shelf life of 24 hours at room temperature (25°C). What is the estimated shelf life in a refrigerator at 8°C? 

5.            An antibiotic solution has a shelf life of 48 hours in the refrigerator (4°C). What is its estimated shelf life at room temperature (28°C)?

6.            A drug solution has a shelf life of 90 days in the refrigerator (28°C). What is its estimated shelf life at room temperature (28°C)?

7.            Which of the following is not a method of sterilization of dosage forms?

 

a.            Centrifugation

 

b.            Dry heat

 

c.             Autoclave

 

d.            Irradiation

 

e.            Filtration

 

8.            Which of the following are modes of action of preservatives of some dosage forms (Select all that apply):

a.            Oxidation of cellular constituents

 

b.            Modification of cell membrane permeability c. Lysis and cytoplasmic leakage

d.            Irreversible coagulation of cytoplasmic constituents

 

e.            Inhibition of cellular metabolism

 

f.             Modification of cell membrane permeability

 

h. hydrolysis

 

9.            Which of the following is not a Compendia Requirements for Capsules?

 

a)            Containers for dispensing capsules

 

b)            Disintegration test for capsules

 

c)            Dissolution test for capsules

 

d)            Weight variation

 

e)            stability testing

 

f)             moisture permeation test

 

e) Content formation *supposed to be either content uniformity or content labeling requirement

 

10.          Which of the following powders is most likely to liquefy upon absorption of moisture?

 

a.            Efflorescent

 

b.            Hygroscopic

 

c.             Deliquescent

 

d.            Dusting

 

e.            Dusting and Hygroscopic