University of Texas, Rio Grande Valley - CLSC 2429

Chapter 14

1)Phagocytes were first reported in which organism and by who?

2.) Which leukocytes contain histamine and which is not part of the innate immune system?

3.) Which are myeloid and which are lymphoid cells?

4.) The skin and mucous membranes are mostly involved in what type of immunity?

5.)Which cells are primarily involved in all the immune response?

6.) What antimicrobial substances compliment the physical barriers of innate immunity and how?

7.) What is the hematopoietic (pluripotent) stem cell and where is it found?

8.) What is phagocytosis? Name and describe the phases in this process.

9.) Describe how the skin and the mucous membranes function as first-line of defense.

10.) Which phagocytic cells are found in the tissues

11.) How are surface receptors different from cytokines?

12.) How do cells comm. with each other so as to mount a coordinated response to microbial invasion?

13.) Generally, what are Pattern Recognition Receptors and what do they detect?

14.) Identify and elaborate on the 3 major protective outcomes of compliment activation.

15.) Describe the complement system and the pathways involved in its activation

16.)How are membrane attack complexes different from granulomas?

17.) Which complement proteins are involved in inflammation and enhancement of phagocytosis?

18) Which complement protein is involved in opsonization?

19.) What is significant about C3a and C5a?

20.) Which group of organisms are more susceptible to complement lysis and why?

21.)What is the first host response to a nonspecific tissue injury?

22.) During chemotaxis which Leukocytes arrive first at the area of inflammation and how?

23.) Digestion of infectious agents involves which cellular structure?

24.) Describe the exocytosis process of the sentinel and neutrophil cells?

25. What happens when Rig-like receptors detect viral RNA?
26. What receptors are used to slow down circulating neutrophils?

27. T/F: White blood cells called granulocytes are important in innate immunity.
28. T/F: Mast cells are only found in the blood.
29. T/F: Lymphocytes are not involved in the adaptive immune response
30. T/F: Lymphoid progenitor cells only differentiate to form T cells and B cells.
31. T/F: All pathways of complement activation follow the same sequence of events after C3.
32. T/F: Gram-negative bacteria are less susceptible to complement lysis than Gram-positive bacteria.
33. T/F: Interferons are cytokines that are involved in destruction of viruses.
34. T/F: Fever often enhances bacterial survival during an infection.
35. What is an opsonin and give an example?