The University of Oklahoma, Norman

CHEM 3653

Quiz-16:

1)Hypoxia-inducible transcription factor (HIF1). is a transcription factor produced when some types of cancer cells utilize aerobic glycolysis. What enzyme(s). is/are affected by this factor?

a. Most of the glycolysis enzymes and glucose transporters.

2. Most gluconeogenesis enzymes and pyruvate dehydrogenase complex
3. Most TCA cycle enzymes are over produced and pyruvate dehydrogenase complex.
4. Glyoxylate cycle for glucose production.

2. Hexokinase can be inhibited by covalent modification.
   1. True.

b. False

3. Which enzymes in gluconeogenesis bypass the irreversible steps of glycolysis in the MUSCLE.
   1. Hexokinase, phosphofructokinase-1, phosphofructokinase -2, and pyruvate kinase

Amino transferase, phosphoenolpyruvate carboxykinase, fructose-2,6- bisphosphatase, and glucose-6-phosphatase

b. Pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and fructose-1,6- bisphosphatase.

3. Pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6- bisphosphatase, and glucose-6-phosphatase
4. Glycerol kinase, glycerol-3-phosphate dehydrogenase, fructose-2,6- bisphosphatase, and glucose-6-phosphatase
5. Pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6- bisphosphatase, and hexokinase

4. During gluconeogenesis,                                     reaction occurs in endoplasmic reticulum.

a. Glucose-6-phosphatase

2. Pyruvate carboxylase
3. Fructose-1,6-bisphosphatase
4. Aldolase
5. No correct answer.