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University of Illinois, Chicago NURS 531 Chapter 59: Biopharmaceuticals and gene therapy MULTIPLE CHOICE 1)A tetracycline-inducible system has been used experimentally to control the expression of hemoglobin erythropoietin insulin thyroxine growth hormone 2
University of Illinois, Chicago
NURS 531
Chapter 59: Biopharmaceuticals and gene therapy
MULTIPLE CHOICE
1)A tetracycline-inducible system has been used experimentally to control the expression of
- hemoglobin
- erythropoietin
- insulin
- thyroxine
- growth hormone
2. Transfection of the herpes simplex virus gene for thymidylate kinase enables tumor cells to activate
- methotrexate
- cytarabine
- foscarnet
- fluorouracil
- ganciclovir
3. The first proof of gene therapy was obtained by transfection of the gene for
- hemoglobin
- erythropoietin
- adenine deaminase
- a1-antitrypsin
- phosphorylase
4. Clinical trials are in progress involving injection of adenoviral vectors containing the human p53 tumor suppressor gene into
- head and neck tumors
- ovarian tumors
- breast tumors
- glioblastoma
- colon tumors
5. Oral gene therapy may be possible using
- viral vectors for gene transfection
- microspheres loaded with plasmid DNA
- liposomes containing plasmids
- naked plasma DNA
- DNA enclosed in cyclodextrin
6. One of the disadvantages of using adenoviruses as vectors for gene transfection is the
- long-lasting expression of the transfected gene
- transfer of genes to the cytoplasm
- strong host immune response
- persistence of the vector in nervous tissue
- incorporation of the virus into host DNA
7. Retroviral vectors are used to transfer
- genomic DNA
- single-stranded DNA
- transfer RNA
- messenger RNA
- a RNA-DNA hybrid
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