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University of Illinois, Chicago NURS 531 Chapter 59: Biopharmaceuticals and gene therapy MULTIPLE CHOICE 1)A tetracycline-inducible system has been used experimentally to control the expression of   hemoglobin erythropoietin insulin thyroxine growth hormone 2

Nursing Jul 07, 2021

University of Illinois, Chicago

NURS 531

Chapter 59: Biopharmaceuticals and gene therapy

MULTIPLE CHOICE

1)A tetracycline-inducible system has been used experimentally to control the expression of

 

  1. hemoglobin
  2. erythropoietin
  3. insulin
  4. thyroxine
  5. growth hormone

2.    Transfection of the herpes simplex virus gene for thymidylate kinase enables tumor cells to activate

 

  1. methotrexate
  2. cytarabine
  3. foscarnet
  4. fluorouracil
  5. ganciclovir

3.    The first proof of gene therapy was obtained by transfection of the gene for

 

  1. hemoglobin
  2. erythropoietin
  3. adenine deaminase
  4. a1-antitrypsin
  5. phosphorylase

 

 

4.    Clinical trials are in progress involving injection of adenoviral vectors containing the human p53 tumor suppressor gene into

 

  1. head and neck tumors
  2. ovarian tumors
  3. breast tumors
  4. glioblastoma
  5. colon tumors

 

 

 

5.    Oral gene therapy may be possible using

 

  1. viral vectors for gene transfection
  2. microspheres loaded with plasmid DNA
  3. liposomes containing plasmids
  4. naked plasma DNA
  5. DNA enclosed in cyclodextrin

 

 

6.    One of the disadvantages of using adenoviruses as vectors for gene transfection is the

 

  1. long-lasting expression of the transfected gene
  2. transfer of genes to the cytoplasm
  3. strong host immune response
  4. persistence of the vector in nervous tissue
  5. incorporation of the virus into host DNA

7.    Retroviral vectors are used to transfer

 

  1. genomic DNA
  2. single-stranded DNA
  3. transfer RNA
  4. messenger RNA
  5. a RNA-DNA hybrid

 

 

 

 

 

 

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