3.

disrupts phospholipid metabolism

4.

inhibits folate synthesis

5.

uncouples oxidative phosphorylation

4.

Which drug may enable a radical cure of malaria due to Plasmodium vivax?

1.

primaquine

2.

mefloquine

3.

chloroquine

4.

quinine

5.

proguanil

5.

Malarial resistance to proguanil results from single-point mutations in genes encoding

1.

DNA polymerase

2.

RNA polymerase

3.

folate synthase

4.

dihydrofolate reductase

5.

glucose-6-phosphate dehydrogenase

6.

Acute amebic dysentery is most effectively treated with

1.

diloxanide only

2.

tinidazole only

3.

tinidazole followed by diloxanide

4.

diloxanide followed by tinidazole

5.

tinidazole followed by metronidazole

7.

Inhibition of mitochondrial electron transport in susceptible protozoans is the likely mechanism of action of

1.

artemisinin derivatives

2.

pyrimethamine

3.

halofantrine

4.

chloroquine

5.

atovaquone

8.

Which drug is administered orally in the treatment of visceral leishmaniasis and causes few side effects?

1.

miltefosine

2.

sodium stibogluconate

3.

pentamidine

4.

suramin

5.

amphotericin B