University of Illinois, Chicago

NURS 531

Chapter 42: Analgesic drugs

MULTIPLE CHOICE

1)Opioids activate descending pathways that inhibit pain transmission by acting on neurons in the

1. dorsal horn
2. thalamus
3. periaqueductal grey matter
4. nucleus raphe magnus
5. locus coeruleus

8.    Activation of kappa opioid receptors is primarily responsible for causing

1. supraspinal analgesia
2. euphoria
3. dysphoria
4. respiratory depression
5. physical dependence

9.    Which finding typically occurs in opioid poisoning but not in central nervous system depression due to other causes?

1. coma
2. hallucinations
3. hypertension
4. respiratory depression
5. pinpoint pupils

10.   The pharmacologic properties of morphine are

1. well absorbed from the gut
2. high oral bioavailability
3. rapidly metabolized in neonates
4. converted to active morphine-6-glucuronide
5. excreted unchanged in the urine

11.  Descending inhibition of dorsal horn pain transmission is mediated by neurons that release

1. acetylcholine and dopamine
2. enkephalins, 5-hydroxytryptamine, and noradrenaline
3. glutamate and substance P
4. bradykinin and prostanoids
5. neuropeptides

12.   Opioid drugs inhibit neurotransmitter release partly by

1. opening potassium and calcium channels
2. closing potassium and calcium channels
3. opening potassium channels and closing calcium channels
4. opening calcium channels and closing potassium channels
5. depolarizing pre-synaptic neuronal membranes

13.   Which transmitter is released at the first synapse in the dorsal horn ascending nociceptive pathway?

1. glutamate
2. enkephalin