Homework answers / question archive / University of Illinois, Chicago NURS 531 Chapter 2: How drugs act: general principles MULTIPLE CHOICE 1)The concentration of a drug required to occupy 50 percent of its receptor sites is   the concentration required to produce the maximum physiological effect directly proportional to the drug’s affinity for its receptor inversely proportional to the drug’s affinity for its receptor directly proportional to the drug’s intrinsic efficacy usually determined with the Schild equation   In the presence of a competitive antagonist, the agonist log-concentration effect curve is   shifted to the right without a change in slope or maximum effect shifted to the left without a change in slope or maximum effect shifted to the right with a decreased slope and maximum effect shifted to the left with a decreased slope and maximum effect not shifted right or left but shows a decreased maximum effect     The magnitude of the response to a drug is related to the   total number of receptors for the drug number of receptors occupied by the drug number of vacant receptors in the tissue number of spare receptors in the tissue number of phosphorylated receptors in the tissue The Schild equation shows that the concentration ratio of an agonist required to occupy the same number of receptors in the absence and presence of a competitive antagonist is determined by the   equilibrium constant of the agonist affinity of the agonist for its receptor equilibrium constant of the antagonist total number of available receptors number of spare receptors in the tissue     A partial agonist is typically a drug that   has low affinity for its receptor can only occupy a small fraction of its receptors can only produce a submaximal response requires high doses to produce a maximal response increases the number of spare receptors A type of drug that reduces the slope and maximum response of an agonist is   a non-competitive antagonist a competitive antagonist a physiologic antagonist an inverse agonist a partial agonist Drugs that form covalent bonds with their receptors are usually   reversible competitive antagonists irreversible competitive antagonists partial agonists inverse agonists inverse antagonists       A gradual decrease in the number of drug receptors is most likely to result from exposure to   a competitive antagonist a non-competitive antagonist an agonist an inverse agonist an antimetabolite The total number of receptor binding sites in a preparation and the binding equilibrium constant can be determined from a   total binding versus drug concentration curve dose-response curve Hill-Langmuir equation Scatchard plot Schild plot     Receptor desensitization typically results from   endocytosis of receptors exposure to an inverse agonist irreversible agonist binding spare receptors phosphorylation of receptor protein          

University of Illinois, Chicago NURS 531 Chapter 2: How drugs act: general principles MULTIPLE CHOICE 1)The concentration of a drug required to occupy 50 percent of its receptor sites is   the concentration required to produce the maximum physiological effect directly proportional to the drug’s affinity for its receptor inversely proportional to the drug’s affinity for its receptor directly proportional to the drug’s intrinsic efficacy usually determined with the Schild equation   In the presence of a competitive antagonist, the agonist log-concentration effect curve is   shifted to the right without a change in slope or maximum effect shifted to the left without a change in slope or maximum effect shifted to the right with a decreased slope and maximum effect shifted to the left with a decreased slope and maximum effect not shifted right or left but shows a decreased maximum effect     The magnitude of the response to a drug is related to the   total number of receptors for the drug number of receptors occupied by the drug number of vacant receptors in the tissue number of spare receptors in the tissue number of phosphorylated receptors in the tissue The Schild equation shows that the concentration ratio of an agonist required to occupy the same number of receptors in the absence and presence of a competitive antagonist is determined by the   equilibrium constant of the agonist affinity of the agonist for its receptor equilibrium constant of the antagonist total number of available receptors number of spare receptors in the tissue     A partial agonist is typically a drug that   has low affinity for its receptor can only occupy a small fraction of its receptors can only produce a submaximal response requires high doses to produce a maximal response increases the number of spare receptors A type of drug that reduces the slope and maximum response of an agonist is   a non-competitive antagonist a competitive antagonist a physiologic antagonist an inverse agonist a partial agonist Drugs that form covalent bonds with their receptors are usually   reversible competitive antagonists irreversible competitive antagonists partial agonists inverse agonists inverse antagonists       A gradual decrease in the number of drug receptors is most likely to result from exposure to   a competitive antagonist a non-competitive antagonist an agonist an inverse agonist an antimetabolite The total number of receptor binding sites in a preparation and the binding equilibrium constant can be determined from a   total binding versus drug concentration curve dose-response curve Hill-Langmuir equation Scatchard plot Schild plot     Receptor desensitization typically results from   endocytosis of receptors exposure to an inverse agonist irreversible agonist binding spare receptors phosphorylation of receptor protein          

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8. A gradual decrease in the number of drug receptors is most likely to result from exposure to

 

8. 1. a competitive antagonist
   2. a non-competitive antagonist
   3. an agonist
   4. an inverse agonist
   5. an antimetabolite
9. The total number of receptor binding sites in a preparation and the binding equilibrium constant can be determined from a

 

1. 1. total binding versus drug concentration curve
   2. dose-response curve
   3. Hill-Langmuir equation
   4. Scatchard plot
   5. Schild plot

 

 

10. Receptor desensitization typically results from

 

1. 1. endocytosis of receptors
   2. exposure to an inverse agonist
   3. irreversible agonist binding
   4. spare receptors
   5. phosphorylation of receptor protein