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Select the true statements regarding antibody (specifically, immunoglobulin G) structure

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Select the true statements regarding antibody (specifically, immunoglobulin G) structure.

1.The heavy and light chains are linked by noncovalent and disulfide bonds.

2.The antigen-binding site is formed as a combination of variable domains from one heavy and one light chain.

3.Both the Fab and Fc fragments have variable domains.

4.Only the Fc fragment has constant domains.

5.The antigen-binding site is located in the Fab fragment.