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Homework answers / question archive / Engineering - modelling of processen Short analysis of the transport of calcium ions in a nanopore has to be done in the software program COMSOL
Engineering - modelling of processen Short analysis of the transport of calcium ions in a nanopore has to be done in the software program COMSOL. The specific requirements of the report are listed in the attached document.
Background
Theory and numerical simulations play a major role in the development of improved and novel separation methods. In some cases, computer simulations predict counterintuitive effects that must be taken into account in order to properly optimize a device. In other cases, simulations allow the scientist to focus on a subset of important system parameters. Occasionally, simulations even generate entirely new separation ideas. This exercise considers a model that describe separation of calcium ions through a nanopores and how this is influenced by an electric potential. Examples on how to make nanopores is described by Willmott et al. 2010 and a scanning electron
microscopy image is shown below.
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Figure 1. SEM imaging of (a) the cis- and (b) the trans-pore surfaces at X = 50 mm. (c) Imaging of the bore
of the pore, as viewed from the cis-side. Surfaces were coated prior to imaging, with the membrane held in a stretched position. G R Willmoit et al 2010 J. Phys.: Condens. Matter 22 454116.
The model to be developed is based on the publication by Gomez et al. as it was presented on the
2014 Comsol Conference in Bosten. Their paper can be found here:
httos:/Avww.comsol.com/paper/stochastic-diffusion-of-calcium-ions-through-a-nanopore-in-the-cell-
membrane-cre-18639. Use Comsol modules like Transport of Diluted Species, Mathematics and
Particle Tracing to replicate the findings by Gomez et al.
