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Which of the following statements about biological reactions is true? a) There is enzyme for each and every biological reaction

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Which of the following statements about biological reactions is true?

a) There is enzyme for each and every biological reaction. Explain?

b) All biological reactions need to be coupled to exergonic reactions.

c) The standard free energies of reactions are always negative.

d) The free energy released during ATP hydrolysis depends on temperature. Explain?