Use reciprocal blast (bi-directional best hit) to find the human RefSeq sequence ortholog for mouse RefSeq sequence NM_007527

What is the human ortholog of NM_007527?

If you complete a nucleotide search for NM_007527 there will be a single match for Mus musculus Bcl2-associated X protein (Bax). NM_007527 refers to a protein found in the house mouse called Bax. Bax is a protein that is important in the control of apopotis.

If you do a pubmed search for Bax you will see all kinds of related articles.

Now an ortholog by definition is a gene from different species that evolved from a common ancestral gene by speciation. Normally, orthologs retain the same function in the course of evolution. So you are looking for the human gene that has the same functionality as the mouse Bax.

If you go the blast site you can do a nucleotide:nucleotide search (from this link: http://www.ncbi.nlm.nih.gov/BLAST/Blast.cgi?CMD=Web&LAYOUT=TwoWindows&AUTO_FORMAT=Semiauto&ALIGNMENTS=50&ALIGNMENT_VIEW=Pairwise&CLIENT=web&DATABASE=nr&DESCRIPTIONS=100&ENTREZ_QUERY=%28none%29&EXPECT=10&FILTER=L&FORMAT_OBJECT=Alignment&FORMAT_TYPE=HTML&NCBI_GI=on&PAGE=Nucleotides&PROGRAM=blastn&SERVICE=plain&SET_DEFAULTS.x=34&SET_DEFAULTS.y=8&SHOW_OVERVIEW=on&END_OF_HTTPGET=Yes&SHOW_LINKOUT=yes&GET_SEQUENCE=yes)

From that screen you will enter in the mouse sequence (NM_007527) in the search field and select "refseq_rna" from the choose database dropdown menu. Then hit format and you will get your results.

From there you will see several results. The closest matches are mouse (obviously) and rat. The closest human match is Refsequence: NM_138761 , which is the human Bax protein.

A good review of Bax and all Bcl related proteins is:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12972498&query_hl=7&itool=pubmed_docsum