1)

Which reverse transcriptase inhibitor achieves the highest percentage of plasma drug concentrations in the cerebrospinal fluid?

1.

lamivudine

2.

abacavir

3.

stavudine

4.

zidovudine

5.

efavirenz

2.

The mortality due to Lassa fever is significantly reduced in persons treated with

1.

tribavirin (ribavirin)

2.

foscarnet

3.

ganciclovir

4.

interferon alpha

5.

oseltamivir

3.

Efavirenz inhibits human immunodeficiency virus reverse transcriptase by

1.

competing with nucleotides for the active site of the enzyme

2.

binding near the catalytic site and denaturing it

3.

incorporation into nascent DNA, causing chain termination

4.

inhibiting formation of nucleotide triphosphates

5.

inhibiting maturation of viral polyproteins

4.

The preferred drug for treating active infections of cytomegalovirus is

1.

acyclovir

2.

foscarnet

3.

lamivudine

4.

nevirapine

5.

ganciclovir

5.

Which virus is most susceptible to acyclovir?

1.

cytomegalovirus

2.

Herpes simplex virus

3.

Herpes zoster virus

4.

respiratory syncytial virus

5.

Epstein-Barr virus