1)Discuss the human disorders produced by spontaneously occurring mutations in the biochemical mechanisms for DA synthesis or reuptake

1)Discuss the human disorders produced by spontaneously occurring mutations in the biochemical mechanisms for DA synthesis or reuptake. What are the symptoms produced in each disorder, and what pharmacological treatments are used to counteract those symptoms? Include in your answer the rationale for selection of each kind of pharmacological symptom based on the mutation involved.

2)List the steps involved in 5-HT synthesis, including the name of the enzyme catalyzing each step. Which is the rate-limiting step in the synthetic pathway?