What is a life-time dose and what anticancer drug is it associated with? What increases the toxicity or doxorubicin? What are the acute effect of doxorubicin? What are the classes of family of hormones and antihormones used for anticancer? What is Tamoxifen? What are the indications for tamoxifen? Who is tamoxifen not indicated for use in? What are the adverse effects of tamoxifen? What are the pharcokinetics of Tamoxifen? What is the indication for Hydroxyurea?

1. What is a life-time dose and what anticancer drug is it associated with?

doxorubicin - the total life time dose cannot be exceeded by the cumulative dose

2. What increases the toxicity or doxorubicin?

chest irradiation increases toxicity -- iron chelator dexrazoxane (Zinecard) sometimes useful to protect against cardiotoxicity

3. What are the acute effect of doxorubicin?

alopecia, BMS, N/V, vesicant -- use good Iv technique, on large veins and monitor closesly

4. What are the classes of family of hormones and antihormones used for anticancer?

adrenocorticosteroids, androgens and antiandrogens, anti/estrogens, anti/progestins

5. What is Tamoxifen?

estrogen antagonist used in antivancer with cell cycle independent effects

6. What are the indications for tamoxifen?

estrogen receptor positive breast cancer (blocks the ability of estrogen to stimulate cell growth)

7. Who is tamoxifen not indicated for use in?

pre-menopausal women

8. What are the adverse effects of tamoxifen?

similar to those of estrogen-- hot flashes, N/V, increased pain and tumor and the bones (viewed as a sign drug is working), risk for endometrial cancer

9. What are the pharcokinetics of Tamoxifen?

taken PO, partially metabolized in the liver, eliminated through the bile

10. What is the indication for Hydroxyurea?

used for hematological cancers