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University of Illinois, Chicago NURS 531 Chapter 60: Drug discovery and development MULTIPLE CHOICE 1)Since 1980, the drug development process has been characterized by rising sales and development costs rising sales and declining development costs declining sales and rising development costs declining sales and development costs increasing registration of new compounds 2
University of Illinois, Chicago
NURS 531
Chapter 60: Drug discovery and development
MULTIPLE CHOICE
1)Since 1980, the drug development process has been characterized by
- rising sales and development costs
- rising sales and declining development costs
- declining sales and rising development costs
- declining sales and development costs
- increasing registration of new compounds
2. Phase II clinical trials are primarily concerned with determining
- drug safety in a small group of normal subjects
- drug efficacy and dosage in a small group of diseased patients
- drug pharmacokinetics in a large group of diseased patients
- statistical evidence of drug efficacy in thousands of subjects
- long-term adverse effects after a drug has been marketed
3. The main disadvantage of natural products as lead compounds for drug development is their
- rarity
- complexity
- toxicity
- inactivity
- insolubility
4. The simultaneous preparation of hundreds or thousands of related compounds uses a process called
- high throughput chemistry
- chaotic chemistry
- fractal chemistry
- optimized chemistry
- combinatorial chemistry
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