University of Illinois, Chicago

NURS 531

Chapter 57: Harmful effects of drugs

MULTIPLE CHOICE

1)The teratogenic effect of thalidomide usually causes

1. abnormal heart valves
2. mental retardation
3. testicular atrophy
4. absence of long bones of limbs
5. spina bifida

2.    Female offspring of women who received stilbestrol during pregnancy have an increased risk of

1. lung cancer
2. breast cancer
3. vaginal cancer
4. endometrial cancer
5. heart valve defects

3.    The toxic metabolite of paracetamol, N-acetyl-p-benzoquinone imine, is believed to cause liver failure by

1. inhibiting cytochrome P450 enzymes
2. inhibiting lipid peroxidation
3. depleting reactive oxygen species
4. depleting reduced glutathione
5. activating Ca²⁺ ATPases

4.    Which drug may elicit antibodies to the surface of red blood cells and thereby cause hemolytic anemia?

1. methyldopa
2. hydrochlorothiazide
3. propranolol
4. minoxidil
5. clozapine

5.    Promoters are substances that increase the likelihood of cancer when administered

1. alone
2. before a co-carcinogen
3. after a co-carcinogen
4. before a primary carcinogen
5. after a primary carcinogen

6.    Liver toxicity resulting from an overdose of paracetamol can be prevented by the administration of

1. oxygen
2. acetylcysteine
3. folinic acid
4. ethanol