University of Illinois, Chicago

NURS 531

Chapter 47: Antidepressant drugs

MULTIPLE CHOICE

1)The mechanisms that contribute to the development of mood depression include increased release of

1. cortisol
2. noradrenaline
3. brain-derived neurotrophic factor
4. 5-hydroxytryptamine
5. g-amino-butyric acid

2.    Alternatives to lithium for the prevention and treatment of manic episodes include

1. fluoxetine
2. sertraline
3. carbamazepine
4. phenelzine
5. bupropion

3.    Mirtazapine is believed to produce its antidepressant effect by

1. activating 5-hydroxytryptamine 5-HT2 receptors
2. activating 5-hydroxytryptamine 5-HT3 receptors
3. activating presynaptic a2 adrenoceptors
4. blocking presynaptic a2 adrenoceptors

5. blocking neuronal reuptake of noradrenaline

4.    Which antidepressant drug is used as an adjunct to smoking cessation?

1. fluoxetine
2. bupropion
3. sertraline
4. mirtazapine
5. paroxetine

5.    Ingestion of foods containing tyramine may lead to a hypertensive crisis in persons taking

1. A tricyclic antidepressant
2. mirtazapine
3. a selective serotonin reuptake inhibitor
4. lithium
5. a nonselective monoamine oxidase inhibitor

6.    Selective serotonin uptake inhibitors cause

1. immediate inhibition of serotonin reuptake and mood improvement
2. delayed inhibition of serotonin reuptake and mood improvement
3. immediate inhibition of serotonin reuptake and delayed mood improvement
4. immediate mood improvement and delayed inhibition of serotonin reuptake
5. mood depression followed by mood improvement

7.    Severe cardiac arrhythmias are most likely to result from an overdose of

1. fluoxetine
2. phenelzine
3. mirtazapine
4. sertraline
5. nortriptyline

8.    Serum lithium levels are increased by the concurrent administration of

1. thiazide diuretics
2. desipramine
3. trazodone
4. phenelzine
5. propranolol

9.    The concurrent administration of a selective serotonin reuptake inhibitor and a monoamine oxidase inhibitor is most likely to cause