University of Illinois, Chicago

NURS 531

Chapter 46: Antipsychotic drugs

MULTIPLE CHOICE

1)The glutamate hypothesis of schizophrenia is based in part on the

1. increased glutamate receptor densities found in schizophrenic brains
2. decreased glutamate receptor densities found in schizophrenic brains
3. reduction of schizophrenic symptoms by glutamate antagonists
4. reduction of schizophrenic symptoms by glutamate agonists
5. occurrence of psychotic symptoms in persons given glutamate agonists

2.    Because of the risk of agranulocytosis, periodic blood counts are required in persons receiving

1. haloperidol
2. quetiapine
3. risperidone
4. clozapine
5. sulpiride

3.    The dopamine hypothesis of schizophrenia is primarily supported by the

1. decreased dopamine synthesis found in schizophrenic patients
2. increased excretion of dopamine metabolites in schizophrenic patients
3. increased dopamine D2 receptor density found in schizophrenic patients
4. decreased dopamine D2 receptor density found in schizophrenic patients
5. correlation between dopamine D2 receptor binding and clinical potency of antipsychotic drugs

4.    The primary endocrine effect of most antipsychotic drugs is

1. increased secretion of prolactin
2. decreased secretion of prolactin
3. increased secretion of growth hormone
4. decreased secretion of growth hormone
5. increased secretion of thyrotropin

5.    Compared to typical antipsychotic drugs such as haloperidol, atypical drugs such as clozapine

1. are more effective in reducing the positive symptoms of schizophrenia
2. are less effective in reducing the positive symptoms of schizophrenia
3. cause fewer extrapyramidal motor side effects
4. cause more extrapyramidal motor side effects
5. are proven to be more efficacious in treating schizophrenia

6.    When antipsychotic drugs are administered chronically, the activity of dopaminergic neurons

1. decreases throughout therapy
2. increases throughout therapy