University of Illinois, Chicago

NURS 531

Chapter 45: Antiepileptic drugs

MULTIPLE CHOICE

1)Gabapentin is believed to exert its antiepileptic effect by

1. increasing the synthesis of g-aminobutyric acid (GABA)
2. increasing the release of g-aminobutyric acid (GABA)
3. activating g-aminobutyric acid (GABA)-gated chloride ion channels
4. blocking g-aminobutyric acid (GABA)-gated chloride ion channels
5. inhibiting the release of several neurotransmitters

2.    The efficacy of ethosuximide in the treatment of absence seizures is based on its ability to

1. block voltage-dependent sodium channels
2. activate voltage-dependent sodium channels
3. block T (transient)-type calcium channels
4. activate T (transient)-type calcium channels
5. activated g-aminobutyric acid (GABA)-gated chloride ion channels

3.    Which antiepileptic agent inhibits g-aminobutyric acid (GABA) transaminase and thereby increases the brain content of GABA?

1. vigabatrin
2. carbamazepine

3. tiagabine
4. lamotrigine
5. topiramate

4.    Carbamazepine is used in treating all of the following conditions except

1. bipolar disorder
2. neuropathic pain
3. absence seizures
4. partial seizures
5. generalized tonic-clonic seizures

5.    The antiepileptic effect of zonisamide is due to its ability to

1. block T (transient)-type calcium channels
2. block voltage-gated sodium channels
3. inhibit g-aminobutyric acid (GABA) degradation
4. inhibit glutamate release
5. block glutamate receptors

6.    Hirsutism, megaloblastic anemia, and gum hypertrophy are potential adverse effects of

1. carbamazepine
2. ethosuximide
3. lamotrigine
4. phenobarbital
5. phenytoin

7.    Gabapentin, tiagabine, and zonisamide are primarily used in treating

1. partial seizures
2. generalized tonic-clonic seizures
3. absence seizures
4. myoclonic seizures
5. status epilepticus

8.    Mood depression and psychotic reactions may occur in some patients receiving

1. gabapentin
2. tiagabine
3. lamotrigine
4. vigabatrin
5. zonisamide