University of Illinois, Chicago

NURS 531

Test Bank

Chapter 26: Anti-inflammatory and immunosuppressant drugs

MULTIPLE CHOICE

1)N-acetyl-p-benzoquinone is the hepatotoxic metabolite of

1. aspirin
2. indomethacin
3. ketorolac
4. acetaminophen
5. ibuprofen

2.    The cyclooxygenase-2 isozyme forms products that cause

1. inflammation
2. platelet aggregation

3. fever
4. gastric acid secretion
5. vasoconstriction

3.    The most common adverse effect of most non-steroidal anti-inflammatory drugs is

1. thrombosis
2. skin rash
3. gastrointestinal distress
4. renal impairment
5. hepatitis

4.    High therapeutic doses of aspirin are most likely to cause

1. metabolic acidosis
2. metabolic alkalosis
3. respiratory acidosis
4. respiratory alkalosis
5. hypothermia

5.    Which drug forms a complex that inhibits activation of transcription factors for interleukin-2 by calcineurin?

1. tacrolimus
2. sirolimus
3. azathioprine
4. muromonab-CD3
5. mycophenolate

6.    Which antihistamine lacks significant sedative and muscarinic receptor antagonist actions?

1. meclizine
2. fexofenadine
3. chlorpheniramine
4. diphenhydramine
5. promethazine

7.    Allopurinol is used in treating gout because of its ability to

1. increase uric acid formation
2. decrease uric acid formation
3. increase uric acid excretion
4. increase uric acid degradation
5. inhibit leukocyte migration

8.    Which disease-modifying anti-rheumatoid drug typically has the greatest efficacy and fewest adverse effects?

1. gold sodium thiomalate
2. auranofin
3. penicillamine
4. hydroxychloroquine
5. methotrexate

9.    The most common serious adverse effect of cyclosporine is

1. peripheral neuropathy
2. congestive heart failure
3. nephrotoxicity
4. hypotension
5. alopecia

10.   Which drug is a monoclonal antibody to tumor necrosis factor-alpha?

1. leflunomide
2. etanercept
3. muromonab-CD3
4. infliximab
5. methotrexate

11.  Which drug inhibits a regulatory kinase involved in cytokine-driven T-cell proliferation?

1. prednisone
2. cyclosporine
3. tacrolimus
4. mycophenolate
5. sirolimus

12.   Selective cyclooxygenase-2 inhibitors have been associated with an increased risk of

1. congestive heart failure
2. thromboembolic disorders
3. hypertension
4. atherosclerosis
5. diabetes mellitus

13.   In the treatment of rheumatoid arthritis, anakinra acts as an antagonist of

1. interleukin-1
2. interleukin-2
3. tumor necrosis factor-alpha
4. calcineurin
5. leukotriene receptors