University of Illinois, Chicago

NURS 531

Chapter 11: Individual variation and drug interaction MULTIPLE CHOICE

1)In babies born at term, the ability to conjugate drugs with glucuronate reaches adult levels in about

1. one week
2. one month
3. 8 weeks
4. 6 months
5. 1 year

2.    The bimodal distribution of plasma isoniazid concentrations in a typical human population is the result of a genetically determined variation in

1. acetyltransferase activity
2. glucuronyl transferase activity
3. cytochrome P450 enzymes
4. plasma cholinesterase activity
5. plasma protein binding

3.    Carbamazepine may cause acute porphyria in susceptible persons because the drug

1. inhibits porphyrin excretion
2. increases porphyrin excretion
3. induces d-amino levulinic acid synthase
4. inhibits d-amino levulinic acid synthase
5. induces cytochrome P450 enzymes

4.    Mercaptopurine doses should be reduced in persons receiving allopurinol because

1. mercaptopurine induces metabolism of allopurinol
2. mercaptopurine inhibits metabolism of allopurinol
3. allopurinol induces metabolism of mercaptopurine
4. allopurinol inhibits metabolism of mercaptopurine
5. allopurinol has the same toxicity as mercaptopurine

5.    Idiosyncratic reactions are defined as drug effects that occur in

1. all persons
2. most persons
3. a few persons
4. persons taking a toxic overdose
5. persons abusing a drug

6.    Drugs that inhibit the metabolism of other drugs by cytochrome P450 enzymes include

1. disulfiram
2. allopurinol
3. phenobarbital
4. rifampicin
5. ketoconazole

7.    Atropine slows the absorption of other drugs from the gut primarily by

1. forming an insoluble complex with other drugs
2. causing vasoconstriction
3. inhibiting gastric acid secretion
4. inhibiting gastric emptying