1)

A statistical technique used to pool data from several independent but related studies is called

1.

double-blind technique

2.

randomization

3.

sequential studies

4.

meta-analysis

5.

high-powered trial

2.

The main problem with all types of bioassay is

1.

human error

2.

inadequate instrumentation

3.

biological variation

4.

high cost compared to other techniques

5.

inability to determine potency

3.

If the dose-response curves of two drugs are parallel in a bioassay, it usually indicates that the two drugs

1.

have the same potency

2.

act on the same type of receptors

3.

are identical

4.

are clinically effective

5.

produce a quantal response

4.

Quantal dose-response curves are obtained when studying

1.

all-or-nothing responses

2.

submaximal responses

3.

bimodal responses

4.

partial agonists

5.

pain intensity

5.

The double-blind technique is employed in clinical trials to

1.

facilitate meta-analysis

2.

confuse regulatory agencies

3.

avoid bias in assigning subjects to treatment groups

4.

avoid bias of patients and investigators

5.

obviate the need for a control group

6.

Transgenic mice that overexpress mutated forms of amyloid precursor protein provide a useful model for

studying

1.

Alzheimer’s disease

2.

Parkinson’s disease