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Homework answers / question archive / Florida A&M University PHARMACY PHA 3102 Quiz  1)A 70­kg volunteer is given an intravenous dose of antibiotic, and serum drug concentrations were determined at 1 hour and 6 hours after administration

Florida A&M University PHARMACY PHA 3102 Quiz  1)A 70­kg volunteer is given an intravenous dose of antibiotic, and serum drug concentrations were determined at 1 hour and 6 hours after administration

Health Science

Florida A&M University

PHARMACY PHA 3102

Quiz 

1)A 70­kg volunteer is given an intravenous dose of antibiotic, and serum drug concentrations were determined at 1 hour and 6 hours after administration. The drug concentrations were 4.2 and 0.4 mg/L, respectively. What is the half­life for this drug, assuming first­order elimination kinetics?

a. 1.2 hours b. 1.5 hours

c.             2.5 hours

d.            4.0 hours

e.            6.2 hours

2.            After the administration of a single IV dose (500 mg) of theophylline to a patient, the drug amount­time profile in this patient was described by the following equation: lnC = lnCo ­ 0.115 * t where t= time in hours. What is half­life of theophylline in this patient (hr)?

A) 5 B) 6

C)            7

D)           8

3.            After the administration of a single IV dose (500 mg) of theophylline to a patient, the drug amount­time profile in this patient was described by the following equation: lnC = lnCo ­ 0.115 * t where t= time in hours. What will be the percentage of theophylline left in the body after 10 hr of administration?

A) 32 %

B) 58 %

C) 68 %

D) 50%

E) 90%

4.            A drug has an elimination t1/2 of 10 hours and follows zero­order kinetics. If a single 50­mg dose is given to an adult male patient by IV bolus injection, what percent of the dose is lost in 14 hours?

A) 35%

B) 70 %

C) 85%

D) 94%

E) 15 %

5.            A solution of a drug was freshly prepared at a concentration of 300 mg/mL. After 30 days at 25oC, the drug concentration in the solution was 75mg/mL. Assuming first­order kinetics, when will the drug decline to one­half of the original concentration?

A.10 days B.15 days

C.20 days

D.25 days

E.30 days

6.            If the amount of drug in the body declines from 100% of the dose (IV bolus injection) to 25% of the dose in 8 hours, what is the elimination half­life for this drug? (Assume first­order reaction).

 

A)           0.173 hour

B)            0.75 hours

C)            2 hours

D)           4 min E) 240 min

7.            A new antibiotic drug was given in a single intravenous bolus of 4 mg/kg to five healthy male adults ranging from 23­38 years (average weight 75 kg). Answer the following using the equation Cp = 78e­0.46t (assume units of µg/mL for Cp and hour for t)

a)            How much of the drug is left in the body if after 4 Hours?

b)            Assuming the drug is no longer effective when the levels decline to less than 2 µg/mL, when should you administer the next dose?

8.            A single IV injection containing 500 mg of cefamandole nafate is given to an adult female patient (63 years, 55 kg) for a septicemic infection. The volume of distribution is 0.1L/Kg and the elimination half­life is 0.75 hour. Assuming the drug is eliminated by first­order kinetics, calculate the following:

a)            The initial plasma concentration (Cp)

b)            The amount of the drug in the body 4 hours after the dose is given

c)            The time for the drug to decline to 0.5 ug/mL, the minimum inhibitory concentration for streptococci. 

If the half­life for decomposition of a drug is 12 hours, how ling will it take for 125mg of the drug to decompose by 30%? Assuming first order kinetics and a t a constant temperature:

 

 

 

10.Heat of vaporization of active drug chemical is a measure of which of the following factors?

a.            Solubility in body fluids

b.            Diffusion through human cell membrane

c.             Chemical stability at elevated temperatures

d.            The energy released from the degradation of a drug

e.            Volatility or evaporation rate

 

11.Which of the following factors are related to drug particle size with oral dosage form? (Select all that apply)

a.            Uniformity of drug dosage content in each dosage form unit

b.            Properties such as taste, color, and texture if the medicine

c.             bioavailability

d.            Flow rates of powder mixtures in manufacture machines

e.            Drug dissolution rate

 

12. If the amount of drug in the body declines from 100% of the dose (IV bolus injection) to 15% of the

dose in 24 hours, what is the elimination half­life for this drug? 

13.A drug has an elimination t ½ of 10 hours and follows first order­kinetics. If a single 50­mg dose is given to an adult male patient by IV bolus injection. What percent % of the dose is lost in 14 hours?

14.If the amount of drug in the body declines from 100% of the dose (Iv bolus injection) to 15% of the dose in 24 hours. What is the elimination half­life (in hours) for this drug?

 

 

15.A drug suspension (125mg/ml) decays by zero order kinetics with a reaction rate constant of 0.5mg/ml/h. What is the concentration of intact drug remaining after 3 days (72 hours), and what is its t ½? This is what’s left= 36, t 1/2 = 125

Which of the following are appropriate compounding practices? Preparation of components into formulation: (Select all that apply).

a.            For the purpose of research or teaching

b.            For chemical analysis and not for sale or dispensing

c.             For a patient as the result of a prescription drug order

d.            For resale by other local pharmacies

e.            In the limited amounts in anticipation of receiving prescription drug order

 

16.All of the following pharmaceutical items are subject to regulation by cGMP except:

a.            Implantable insulin infusion

b.            Peptides produced by recombinant DNA technology

c.             Heparin prefilled syringes

d.            Empty plastic prescription vials

e.            Intravenous catheters impregnated with antibiotics

.17. All of the following c are subject to regulation by cGMPs except:

a.            Implantable insulin infusion

b.            Peptides produced by recombinant DNA technology

c.             Heparin prefilled syringes d. None of the above

18.Toxicological profiles for drugs include all of the following except:

a)            Genotoxicity or mutagenicity studies

b)            Reproduction studies

c)            Chronic adverse effect

d)            Drug Efficacy

e)            Carcinogenicity

19.All of the following may occur during Phase 1 clinical trials of a prospective new drug except:

a)            Testing in human beings for drug safety

b)            Testing in humans beings for drug effectiveness

c)            Evaluating side effects associated with increasing doses

d)            Selecting from among different chemical analogs of a lead compound

20.What is initial concentration of drug if the drug concentration remaining in blood is 7.8 mg/L after 8 hr and half­life is 2.475 hr?

 

 

21.What is the concentration of drug remaining in systemic circulation after 4 hr, if the initial concentration is 16.2 mg/L and elimination rate constant (Kel) is 0.2 hr­1? (Assume the first­ order process).

 

 

 

 

 

22.If the amount of drug in the body declines from 100% of the dose (IV bolus injection) to 25% of the dose in 8 hours, what is the elimination half­life for this drug? (Assume first­order reaction).

 

23.A drug has an elimination t1/2 of 6 hours and follows first­order kinetics. If a single 200­mg dose is given to an adult male patient by IV bolus injection, what percent of the dose is lost in 24 hours? (Assuming is first order kinetics)

 

24.All of the following are physical­chemical factors that favor the diffusion of a drug across mammalian membranes except:

a)            The unionized form of the drug

b)            Hydration of ionized drugs

c)            Small particles size

d)            Large concentration gradient

 

e)            Lipid solubility

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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