University of MinnesotaBIOL MISC

Hunting the Nightmare Bacteria Video Worksheet

1)What did doctors believe Addy was infected with initially? What were her symptoms?

2. Addy had ‘community-acquired’ resistant staph (as opposed to hospital-acquired). How did Addy likely become infected initially?

3. What secondary infection did Addy acquire in the hospital? How did she acquire it?

4. What does pan-resistant mean?

5. Why are Gram negative bacteria often more difficult to treat?

6. What treatment provided Addy with her best chance of survival?

7. What have been the lasting effects of Addy’s infections?

8. How was David Ricci injured in India?

9. He was infected with CRE (carbapenem-resistant enterobacteriaceae). What gene invokes this type of resistance?

10. Are bacteria with the NDM-1 gene found in the environment?

11. About how many other types of resistant bacteria did they find?

12. If a spreading infection cannot be cured, what has to happen?

13. Where do many Gram negative bacteria live in the body?

14. In 2008, a patient in ICU was diagnosed with KPC (Klebsiella pnuemoniae carbapenemase- producing) at the Clinical Center at the National Institutes of Health (NIH). Five weeks after the patient was released, KPC turned up in a respiratory culture. Do they know how it was spread? Were they able to get rid of it at that time?

15. Six months after patient #1, there was another outbreak. How many patients were infected and how many died?

16. The more antibiotics are used, the more                                                                                               they become.

17. Alexander Fleming, the discoverer of penicillin saw resistance as early as            .

18. True or False: Up to ½ of antibiotic use is inappropriate.

19. Why is it more lucrative for drug companies to develop drugs for chronic illnesses than antibiotics?

20. Approximately how much does it cost to bring a new drug to market?

21. In March 2013, The CDC finally raised the alarm about antimicrobial resistance. March 2013, the Obama administration put $60 million in the resistance program in the proposed budget (doubled the funding). That was several years ago and there is a different administration in the