University of Texas, Brownsville - CLSC 2429 for Chapter 15 1)What two cells are mostly responsible for killing virally infected cells? How does interferon help in the killing of virally infected cells? MHC class II molecules are produced by which cells? Where does the variable region of an antibody occur? How are antibodies specifically defined? What is an “antigenic determinant”? Where do T-cells mature? Where do B-lymphocytes (cells) mature? Cell-mediated immunity, T cytotoxic cells, and MHC I are all involved in reacting to         Which of the antibodies: IgD, IgE, IgA, or IgM is a pentamer? What do plasma cells do?   Which is the most abundant immunoglobulin made by the body? What is “gene rearrangement” responsible for?