1) At nucleotide 380 there is a change in the DNA that changes an RNA codon from UGC to UCC

1) At nucleotide 380 there is a change in the DNA that changes an RNA codon from UGC to UCC. What happens to the amino acid sequence when this mutation occurs? How would that affect the protein structure?  Big change, modest change, or no change?

2) At nucleotide 12 there is a nucleotide change in the DNA that changes a codon in the RNA from GAC to GAG. What happens to the amino acid sequence when this mutation occurs? How would that affect the protein structure?  Big change, modest change, or no change?  (USE THE AMINO ACID STRUCTURES IN APPENDIX 3 IN YOUR TEXT)