1)What was the name of the first federal legislation aimed at regulating the sale of marijuana? Is that law still in effect now? 2)(a) Describe the principal routes of cannabis administration

1)What was the name of the first federal legislation aimed at regulating the sale of marijuana? Is that law still in effect now?

2)(a) Describe the principal routes of cannabis administration. Which of these routes provides the greatest cannabinoid bioavailability? (b) Name two major metabolites of THC.

3)Discuss the main characteristics of cannabinoid receptors, including receptor subtypes, receptor distribution within and outside of the brain, and whether the receptors are metabotropic or ionotropic.