When should albuterol be used with cautrion/ What is Salmeterol? When should salmeterol not be used? What are the side effects of salmeterol? What are the drug drug interactions of salmeterol? What is the prototype xanthine derivative? What is the mechanism of action of theophylline? What are the physiological effects of theophylline? What is the metabolism of theophylline like? What two drugs are metabolized into theophylline?

1. When should albuterol be used with cautrion/

HTN, cardiac arrythmias, diabetes, hyperthyroidism and seizures

2. What is Salmeterol?

The long acting, slow onset, more potent B2 agonist used for the prevention of asthmatic attacks

3. When should salmeterol not be used?

In asthmatic/respiratory emergencies because it has a slow onset

4. What are the side effects of salmeterol?

tend to accumulate in the body -> provides action but can definitely cause txicicty

5. What are the drug drug interactions of salmeterol?

MAOI and trycyclic antidepressants increase the effects of salmeterol

6. What is the prototype xanthine derivative?

Theophylline

7. What is the mechanism of action of theophylline?

inhibits the action of phosphodiesterases which cleaves cAMP ---> prolonging the action of cAMP, and reduces adenosine receptor mediated bronchoconstriction by inhibiting the conversion of cAMP -> 5AMP

8. What are the physiological effects of theophylline?

bronchodilation, decreased degranulation of mast cells --> decreased histamine release, and decrease in pulmonary secretions, also blocks bronchoconstriction

9. What is the metabolism of theophylline like?

converted into caffeine by the hepatic metabolism (about 30% of each dose), and then further metabolism totally inacticates the parent compound

10. What two drugs are metabolized into theophylline?

aminophylline and oxtriphylline