1. Why is access to pseudophedrine limited?

can be used to make meth

2. What is the prototype antihistamine?

Fexofenadine

3. What is the mechanism of action of antihistamines?

they bind to the H-1 receptors and block their action

4. What are the indications for antihistamines?

histamine induced hypersensitivity reactions

5. What are the pharmacokinetics of antihistamines like?

oral absorption, gets throughout the entire body including the cnS (may be responsible for sedating effects)

6. What are the contraindications of fexofenadine?

asthma or COPD because the drying effect can worsen the mucus plugs, rhinitis, viral illness and colds, and children under 12

7. What are the adverse effect of fexofenadine?

flu-like symptoms, N/V and dysmennorhea, may cause some idiosyncratic sedation

8. Why was terfenadine moved from the market how does this relate to fexofenadine?

terfenadine is closely related to fexofenadine, and had the effect of prolonging the QT interval, however fexofenadine has a much lower potential

9. What is the prototype sedating antihistamine?

diphenhydramine (benadryl) due to the CNS antimuscarinic effects --> drowsiness

10. What are the indications of Diphenhyrdramine?

common ingredient for over the counter anti-anxiety, motion sickness and cold/hay fever