What are the affected tissues of cystic fibrosis? What is rhinitis? What are the mediators of inflammation? Where is histamine made and stored? Where are histamines found in the highest concentrations? What are the triggers of histamine release? How is histamine broken down? What is the difference between fast/copious release of histamine and slow/minimal relase? How is histamine release enduced? Where does histamine bind?

1. What are the affected tissues of cystic fibrosis?

lung, reproductive tract, pancreas, and sweat glands

2. What is rhinitis?

inflammation of the nasal mucosal membranes due to viruses and hypersensitivity

3. What are the mediators of inflammation?

histamine and leukotryines

4. Where is histamine made and stored?

lungs, skin and GI tract stored in mast cells and basophils

5. Where are histamines found in the highest concentrations?

in the tissues with external contact

6. What are the triggers of histamine release?

cold viruses, bacteria, trauma, toxins, dust and allergens

7. How is histamine broken down?

by the tissues where it is released, but it has a limited rate

8. What is the difference between fast/copious release of histamine and slow/minimal relase?

fast copious release leads to a systemic rxn, and a slow/minimal release leads to a smaller localized reaction

9. How is histamine release enduced?

the antigen attaches to lymphocytes --> creation of IgE antibodies--> bind to the surface of mast cells and basophils --> antigen binds to antibodies --> cells are stimulated to degranulate which releases histamines and leukotryines

10. Where does histamine bind?

to H1, H2, and H3 receptors