What is the mechanism of Carmustine? What should be done with the patient on carmustine? Are antibiotc antitumor agents cycle specific? What is the prototype antibiotic anticancer agent? What are the three ways doxyrubicin kills cells? What are the indications of Doxyrubicin? What is the limiting toxicity of Doxyrubicin? What is the dosage form and the bioavailability of doxyrubicin? What are the side effects of doxyrubicin? What is true of doxyrubicin and hepatic patients?

1. What is the mechanism of Carmustine?

acts to cross link Dna and prevent replication

2. What should be done with the patient on carmustine?

give antimetics, monitor WBC, and prevent infection

3. Are antibiotc antitumor agents cycle specific?

generally no

4. What is the prototype antibiotic anticancer agent?

Doxyrubicin

5. What are the three ways doxyrubicin kills cells?

1. binds to DNA
2. Binds to and attacks cell membranes
3. Generates oxygen free radicals that attack DNA

6. What are the indications of Doxyrubicin?

many different cancers, including breast and lung, acute lymphocytic leukemia and lymphomas

7. What is the limiting toxicity of Doxyrubicin?

cardiotoxicity is limiting, heart and tumors low in superoxide dismutase, protector against oxygen free radicals

8. What is the dosage form and the bioavailability of doxyrubicin?

Only give IV, does not cross BBB

9. What are the side effects of doxyrubicin?

metabolized and eliminated in bile and urine - causes urine to turn red or pink

10. What is true of doxyrubicin and hepatic patients?

the dose must be reduced