What is the normal neutrophil count? What are the non-hemotologial side effects of topotecan? What are the limiting toxicities of Etoposide? What are the pharmacokinetics of Etoposide? What is the mechanism of action of etoposide? What are the side effects of etoposide? What is true of the toxicity of non-cell cycle specific drugs? What are the classes of alkylating agents? What is the prototype nitrogen mustards? What is the prototype Niytosoureas?

1. What is the normal neutrophil count?

should be greater than 1.5 K cells/mm3 and platelets should be greater than 100k cell mm3

2. What are the non-hemotologial side effects of topotecan?

N/V, GI upset, alopecia and fatigue

3. What are the limiting toxicities of Etoposide?

BMS

4. What are the pharmacokinetics of Etoposide?

Given IV, can cause anaphylaxis when given rapidly so requires a slow administrations

5. What is the mechanism of action of etoposide?

inhibits the DNA synthesis in S and G2 phase because it prevents the repair of DNA bbreaks by topoll

6. What are the side effects of etoposide?

radiation recall (rash in area where pt received radiation), irritant can cause pain along IV site, metallic taste (suck on candy(

7. What is true of the toxicity of non-cell cycle specific drugs?

they are generally seen to be more toxic than cycle specific drugs due to the toxicities

8. What are the classes of alkylating agents?

nitrogen mustards, nitrosoureas, and other alkylator drugs

9. What is the prototype nitrogen mustards?

Cyclophosphamide

10. What is the prototype Niytosoureas?

carmustine