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Homework answers / question archive / What is Paclitaxel mechanism of action? What are the indications for Paclitaxel? What is true of 10% of patient with the use of Paclitaxel? What are the major limiting toxicities of Paclitaxel/ what is the prototype topomirase 1 inhibitor? What is the prototype topoisomerase 2 inhibitor? What is the action of a topoimerase? What is the effect of blocking topoimerases? What phase of the cycle to topoisomerase effectively block? What are the limiting toxicities of Toptecan?
creates unusually stable tubulin molecules that stack and fail to depolymerize so the stell stays frozen in metaphase
ovarian and breast cancer through the IV
they need to pretreated with corticosteroids and antihistamines to prevent anaphylazxis due to hypersenstivity with diluents
BMS and neurotoxicity
Topotecan
Etoposide
enzymes that break and then re-anneal DNA in order to allow it to unwind, so that it may be replicated and repaired -- Type 1 - only cuts one strand of DNA and Type 2 - cuts both strands of DNA
leads to DNA breaks that are not repaired causing cell death
S and G2 phase of the cell cycle
BMS and thrombocytopenia (avoid infections and cuts in patients)