What are the indications for vincristine? What is the administration route of vincristine and why? What is a vesicant effect? What are the toxicities of vincristine What causes the neurological toxicities of vincristine and what are the effects? Who should vincristine be cautioned with? What are the contraindications for vincristine? What are the side effects of vincristine? What is Paclitaxel? What molecule is used to make the mitotic spindle? what is the normal cycle?

1. What are the indications for vincristine?

acute lymphocytic leukemia and other lymphmos,

2. What is the administration route of vincristine and why?

only administered through an IV -- because elsewhere can cause tissue damage due to the vesicant effect

3. What is a vesicant effect?

when a medication is capable of causing blisters on the skin -- use extravasation precautions (if it leaks out of IV - it will cause burns and vesicles)

4. What are the toxicities of vincristine

vesicant can cause tissue damage, neurological toxicities, and more severe toxicities related to the cumulative dose

5. What causes the neurological toxicities of vincristine and what are the effects?

the tubulins involved in the structure of the neuron are similar to those involved in cell division, can result in numbness and tingling in the fingers and the toes

6. Who should vincristine be cautioned with?

those with pre-existing neurological conditions and those with liver damage may require a lower dose

7. What are the contraindications for vincristine?

Charcot- Marie- tooth syndrome -- a demylinating syndrome in the body

8. What are the side effects of vincristine?

constipation and drug interactions with opiates

9. What is Paclitaxel?

An antimitotic drug that has the opposite effects on tubulin than vincristine

10. What molecule is used to make the mitotic spindle? what is the normal cycle?

in metaphase stacked tubulin molecule makes the spindle, and then dissolves after anaphase to allow the cell to divide