Homework answers / question archive / COLLEGE OF LIBERAL ARTS AND SCIENCES SCHOOL OF LIFE SCIENCES TIMED ASSESSMENT SEMESTER 2 2020/21 Module Code: Module Title: Module Leader: Release Time: Submission Deadline: 6BIOM002W Cellular and Molecular Pathology Dr Tony Madgwick 10/05/2021 14:00 BST (GMT+1) 11/05/2021 14:00 BST (GMT+1) Instructions to Candidates: Please read the instructions below before starting the paper • Module specific information is provided below by the Module Leader • The Module Leader will be available in the first hour of timed release to respond to any queries via a discussion board on blackboard • As you will have access to resources to complete your assessment any content you use from external source materials will need to be referenced correctly

COLLEGE OF LIBERAL ARTS AND SCIENCES SCHOOL OF LIFE SCIENCES TIMED ASSESSMENT SEMESTER 2 2020/21 Module Code: Module Title: Module Leader: Release Time: Submission Deadline: 6BIOM002W Cellular and Molecular Pathology Dr Tony Madgwick 10/05/2021 14:00 BST (GMT+1) 11/05/2021 14:00 BST (GMT+1) Instructions to Candidates: Please read the instructions below before starting the paper • Module specific information is provided below by the Module Leader • The Module Leader will be available in the first hour of timed release to respond to any queries via a discussion board on blackboard • As you will have access to resources to complete your assessment any content you use from external source materials will need to be referenced correctly

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COLLEGE OF LIBERAL ARTS AND SCIENCES SCHOOL OF LIFE SCIENCES TIMED ASSESSMENT SEMESTER 2 2020/21 Module Code: Module Title: Module Leader: Release Time: Submission Deadline: 6BIOM002W Cellular and Molecular Pathology Dr Tony Madgwick 10/05/2021 14:00 BST (GMT+1) 11/05/2021 14:00 BST (GMT+1) Instructions to Candidates: Please read the instructions below before starting the paper • Module specific information is provided below by the Module Leader • The Module Leader will be available in the first hour of timed release to respond to any queries via a discussion board on blackboard • As you will have access to resources to complete your assessment any content you use from external source materials will need to be referenced correctly. Whenever you directly quote, paraphrase, or summarise someone else’s ideas, you have a responsibility to give due credit to that person for their work. Support can be found at https://www.westminster.ac.uk/current-students/studies/study-skills-and-training/researchskills/referencing-your-work • This is an individual piece of work so do not collude with others on your answers as this is an academic offence. • Plagiarism detection software will be in use. • Where the University believes that academic misconduct has taken place the University will investigate the case and apply academic penalties as published in Section 10 Academic Misconduct regulations. • If you are submitting a Blackboard Assignment, please see this web page for guidance. In case of problems with submission, you will have TWO opportunities to upload your answers and the last uploaded attempt will be marked if submitted by the published deadline. • Candidates are advised that all answers must be submitted through the appropriate Turnitin link before the end of the 24h period. Any submissions received after that period will be awarded zero. Module Specific Information This timed assessment is in TWO SECTIONS, A and B. Section A consists of ONE question which must be attempted. Section B consists of five questions of which TWO should be attempted. Do not attempt more than the requested number of questions. Every question is to be answered in a separate Word document and uploaded into the corresponding Turnitin link. You must adhere to the following instructions: 1. Use Arial font, size 12 with 1.5 line spacing for all of your work. 2. Section A has a word limit of 800 words ± 10%, excluding any text references. 3. Each question in Section B has a word limit of 600 words ± 10%, excluding any text references. 4. This is an Open Book exam. As a minimum, content sources should be cited in-text and these should include any sources of figures, images or tables. Candidates are advised to read the whole paper before starting to answer any of the questions. Where appropriate, diagrams and tables should be used to illustrate your answers. This paper carries 50% of the marks for the module. Page 3 of 4 COLLEGE OF LIBERAL ARTS AND SCIENCES Module: Cellular and Molecular Pathology Module Code: 6BIOM002W Date: Semester 2 2020/2021 Section A There is ONE question in this section. Section A carries 40% of the marks available. Question Case Summary Within the module, you have been studying a case presentation that integrates a range of techniques used in the histological and molecular investigation of a cancer. You have already reviewed in your coursework the histology of the patient’s cancer and drawn conclusions from biomarker expression revealed by immunohistochemistry. The composite image above shows the results of an investigation of a secondary breast cancer found in patient’s liver. An initial assessment of the biopsy using an antibody against HER2 gave the result shown in C. Therefore, a CISH (DDISH) test was ordered and the result is shown in D. Referring to the information shown in the figure, evaluate the principle of the “HER-2 testing” algorithm and its application to the treatment of patients. Page 4 of 4 COLLEGE OF LIBERAL ARTS AND SCIENCES Module: Cellular and Molecular Pathology Module Code: 6BIOM002W Date: Semester 2 2020/2021 Section B Answer TWO of the following questions. Section B carries 60% of the marks available. Every question is worth equal marks. 1. Critically evaluate the contribution of histopathology to the staging of solid cancers. Support your answer with at least two examples explored in this module. 2. Name at least TWO special stains and critically evaluate their use on kidney biopsies of patients with nephrotic syndrome. 3. Critically evaluate the use of stem cells in regenerative medicine. Include suitable examples in your answer. 4. Evaluate the significance of chromosomal translocations in the diagnosis of haematological malignancies. Use at least two suitable examples to support your answer. 5. “The somatic mutation theory for the origin of cancers rests upon the notion of the proliferative quiescence of cells.” Evaluate this statement. END OF TIMED ASSESSMENT