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Chapter 20

54) Rationalize the pKa trends among amines, and how this correlates to reactivity.

55) Rationalize the pKa trends among phenols and how this correlates to reactivity compared to alcohols.

56) Explain the difference between benzyne addition and nucleophilic aromatic substitution.

Chapter 21

57) Describe the basic organometallic mechanistic steps that are a hallmark of transition metal chemistry and apply to the mechanism of alkene hydrogenation

58) apply these steps to the major Cross-coupling (Heck, Suzuki) reactions.

59) apply these reactions in designed syntheses of simple pharmaceutical reagents.

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