Mutations that favor the oxidation of the heme iron(II) to iron(III) can cause When unstable hemoglobin is degraded; degradation products often cause cell lysis, leading to a condition called Sickle cell hemoglobin does not form fibers in the ______ form

1. Mutations that favor the oxidation of the heme iron(II) to iron(III) can cause

cyanosis

2. When unstable hemoglobin is degraded; degradation products often cause cell lysis, leading to a condition called

hemolytic anemia

3. Sickle cell hemoglobin does not form fibers in the ______ form.

R

4. The ___________ model of allosterism requires subunits to change conformation simultaneously.

symmetry

5. The absence of 2,3-BPG causes hemoglobin's affinity for oxygen to

increase

6. An increase in pCO2 causes hemoglobin's affinity for oxygen to

decrease

7. Hemoglobin's subunits bind oxygen in a ________ manner.

positively cooperative

8. The conversion of hemoglobin from the T to the R state requires breaking of ________ involving C-terminal residues.

Ion pairs

9. In the _____________ state of hemoglobin, the iron ion is out of the plane of the porphyrin ring.

T

10. When oxygen binds to heme, the oxygen forms a hydrogen bond with

His E7