University of Illinois, Chicago

NURS 531

Chapter 51: Antibacterial drugs

MULTIPLE CHOICE

1)Benzylpenicillin is the first drug of choice for treatment of infections due to

1. Pseudomonas aeruginosa
2. Legionella pneumophila
3. Haemophilus influenzae
4. Treponema pallidum
5. Pasteurella multocida

2.    Red-green color blindness is a dose-related adverse effect of

1. cycloserine
2. ethambutol
3. rifampicin
4. isoniazid
5. streptomycin

3.    Resistance to cephalosporin antibiotics is most likely to result from

1. phosphorylation by bacterial kinases
2. inactivation by bacterial b-lactamase
3. decreased affinity of dihydrofolate reductase
4. increased efflux by bacterial transport proteins
5. decreased ribosomal affinity for the drugs

4.    Penicillins that are active against strains of Pseudomonas aeruginosa include

1. piperacillin
2. ampicillin
3. benzylpenicillin
4. amoxicillin
5. phenoxymethylpenicillin

5.    Respiratory tract infections caused by Nocardia or Pneumocystis are often treated with

1. co-trimoxazole
2. gentamicin
3. azithromycin
4. tetracycline
5. chloramphenicol

6.    Cilastatin inhibits the degradation of imipenem by

1. hepatic enzymes
2. gut wall enzymes
3. renal enzymes
4. pulmonary enzymes
5. plasma enzymes

7.    Chloramphenicol is not used for trivial infections because it may rarely cause

1. liver failure
2. pancytopenia
3. heart failure
4. pulmonary fibrosis

5. convulsive seizures

8.    Infections due to penicillinase-producing strains of Neisseria gonorrhoeae may be most effectively treated with

1. tetracycline
2. gentamicin
3. erythromycin
4. vancomycin
5. ofloxacin

9.     A genetically determined variation of hepatic acetyltransferase activity accounts for differences in the elimination half-life of

1. rifampicin
2. isoniazid
3. pyrazinamide
4. ethambutol
5. cycloserine

10.  Tetracycline should not be given to pregnant women or young children because of the risk of

1. retarded bone development
2. ototoxicity
3. bone marrow depression
4. myositis and rhabdomyolysis
5. hypoplasia and staining of the teeth

11.  Arthropathy manifested as painful joints is most likely to occur in younger individuals treated with

1. ciprofloxacin
2. tetracycline
3. azithromycin
4. trimethoprim
5. vancomycin

12.  Quinupristin-dalfopristin is active against some strains of

1. Pseudomonas aeruginosa
2. Enterococcus faecium
3. Escherichia coli
4. Proteus mirabilis
5. Legionella pneumophila