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Homework answers / question archive / University of Illinois, Chicago NURS 531 Chapter 50: Basic principles of antimicrobial chemotherapy MULTIPLE CHOICE 1)Which drug selectively inhibits bacterial RNA polymerase?   cytarabine zidovudine dactinomycin rifampin acyclovir     2

University of Illinois, Chicago NURS 531 Chapter 50: Basic principles of antimicrobial chemotherapy MULTIPLE CHOICE 1)Which drug selectively inhibits bacterial RNA polymerase?   cytarabine zidovudine dactinomycin rifampin acyclovir     2

Nursing

University of Illinois, Chicago

NURS 531

Chapter 50: Basic principles of antimicrobial chemotherapy

MULTIPLE CHOICE

1)Which drug selectively inhibits bacterial RNA polymerase?

 

  1. cytarabine
  2. zidovudine
  3. dactinomycin
  4. rifampin
  5. acyclovir

 

 

2.    Conjugation is an important mechanism for transfer of drug resistance genes between

 

  1. coliform bacteria
  2. staphylococci
  3. enterococci
  4. streptococci
  5. spirochetes

3.    Cycloserine prevents the addition of terminal       residues to the peptide side chain on N- acetylmuramic acid

 

  1. glycine
  2. leucine
  3. methionine
  4. alanine
  5. tyrosine

 

 

4.    Induction of bacterial proteins that enable energy-dependent efflux of drug molecules is an important mechanism of resistance to the

 

  1. penicillins
  2. aminoglycoside antibiotics
  3. tetracycline antibiotics
  4. macrolide antibiotics
  5. folate reduction inhibitors

5.    Which drug is correctly paired with the type of organism in which it selectively inhibits dihydrofolate reductase?

 

  1. trimethoprim-mammalian
  2. pyrimethamine-mammalian
  3. methotrexate-bacterial
  4. methotrexate-protozoan
  5. methotrexate-mammalian

 

 

6.    Ciprofloxacin selectively binds and inhibits

 

  1. bacterial RNA polymerase
  2. bacterial topoisomerase II
  3. bacterial DNA polymerase
  4. mammalian DNA polymerase
  5. mammalian topoisomerase II

7.    Which antibiotic inhibits translocation of the bacterial peptide chain from the A (acceptor) to the P (peptide) site of the 50S ribosomal subunit?

 

  1. erythromycin
  2. puromycin
  3. streptomycin
  4. tetracycline
  5. chloramphenicol

8.    Inhibition of bacterial transpeptidase and carboxypeptidase is the mechanism of action of

 

  1. bacitracin
  2. vancomycin
  3. b-lactam antibiotics
  4. cycloserine
  5. fusidic acid

 

 

9.    Bacterial drug resistance may occur due to expression of a dihydropteroate synthetase that has decreased affinity for

 

  1. penicillin
  2. chloramphenicol
  3. trimethoprim
  4. sulfonamides
  5. erythromycin

 

 

 

 

 

 

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