1)

Peptide and protein mediators typically

1.

function as fast neurotransmitters

2.

contain intramolecular diphosphate bonds

3.

are easily crystallized

4.

have highly rigid structures

5.

activate cell surface receptors

2.

As pharmacologic agents, most peptides are

1.

easily absorbed from the gastrointestinal tract

2.

rapidly distributed to the brain

3.

usually administered by the transdermal route

4.

rapidly degraded by plasma and tissue enzymes

5.

inexpensive to manufacture

3.

Bosentan is an antagonist of

1.

opioid receptors

2.

angiotensin AT1 receptors

3.

endothelin receptors

4.

bradykinin receptors

5.

platelet fibrinogen receptors

4.

Most neural and endocrine peptide mediators

1.

act on G-protein-coupled receptors

2.

activate ligand-gated ion channels

3.

exhibit protein kinase activity

4.

cause receptor up-regulation

5.

bind to membrane transport proteins

5.

Cyclosporine is a fungal polypeptide used clinically to

1.

diagnose endocrine disease

2.

cause immunosuppression

3.

treat cystic fibrosis

4.

treat thromboembolism

5.

induce labor

6.

Which agent blocks substance P (neurokinin NK1) receptors and thereby prevents nausea and vomiting?

1.

granisetron

2.

promethazine