University of Illinois, Chicago

NURS 531

Chapter 13: Cholinergic transmission

MULTIPLE CHOICE

1)Activation of muscarinic M2 receptors

1. increases calcium conductance
2. increases potassium conductance
3. increases cardiac rate and force
4. causes central nervous system excitation
5. produces vascular smooth muscle relaxation

2.    Succinylcholine is characteristically an agonist at

1. muscarinic M1 receptors
2. muscarinic M2 receptors
3. muscarinic M3 receptors
4. nicotinic receptors in skeletal muscle
5. nicotinic receptors in autonomic ganglia

3.    The second messengers formed by activation of muscarinic acetylcholine receptors include

1. inositol triphosphate
2. cyclic AMP
3. cyclic GMP
4. eicosanoids
5. guanosine triphosphate

4.    Pilocarpine lowers intraocular pressure by

1. decreasing aqueous humor formation
2. contracting the iris sphincter muscle
3. contracting the ciliary muscle
4. relaxing the iris sphincter muscle
5. relaxing the ciliary muscle

5.    The increased release of potassium from denervated muscles by succinylcholine is due to

1. inhibition of cholinesterase
2. desensitization of nicotinic receptors
3. nicotinic receptor up-regulation
4. denervation supersensitivity
5. destruction of the motor end plate

6.    Edrophonium produces reversible inhibition of cholinesterase by

1. binding the anionic site
2. binding the esteratic site
3. binding both anionic and esteratic sites

4. reversibly binding an allosteric site
5. forming a complex with acetylcholine

7.    Pyridostigmine enhances neuromuscular transmission in myasthenia gravis patients by

1. increasing release of acetylcholine
2. inhibiting degradation of acetylcholine
3. causing up-regulation of nicotinic receptors
4. reactivating cholinesterase
5. blocking autoantibodies

8.    Activation of muscarinic M3 receptors leads to

1. smooth muscle relaxation
2. cardiac slowing
3. central nervous system stimulation
4. vasoconstriction
5. exocrine gland secretion

9.    The effects produced by topical ocular administration of atropine include

1. miosis
2. mydriasis
3. lacrimation
4. decreased intraocular pressure
5. conjunctivitis

10.   If a test dose of edrophonium increases muscle weakness in a myasthenia gravis patient being treated with pyridostigmine, it means that

1. the patient does not actually have myasthenia gravis
2. the dose of pyridostigmine is too low
3. the dose of pyridostigmine is too high
4. atropine should be administered
5. none of the above is correct

11.  Atropine poisoning in children typically causes

1. respiratory depression
2. muscle paralysis
3. sweating
4. hyperthermia
5. sedation