University of Illinois, Chicago

NURS 531

Chapter 8: Drug absorption and distribution MULTIPLE CHOICE

1)Concerning the effect of pH on the urinary excretion of drugs, it can be correctly stated that

1. urinary acidification accelerates excretion of weak acids and bases
2. urinary alkalinization accelerates excretion of weak acids and bases
3. urinary acidification accelerates excretion of weak acids
4. urinary alkalinization accelerates excretion of weak acids
5. urinary alkalinization has no effect on excretion of weak bases

2.    Bioavailability is defined as the proportion of ingested drug that

1. is absorbed from the gastrointestinal tract
2. reaches the systemic circulation in an active form
3. crosses the blood-brain barrier
4. is unbound to plasma proteins
5. is distributed to the target tissue

3.    The rectal route of administration

1. provides nearly 100 percent bioavailability
2. is only used for localized effects
3. is suitable for persons with nausea and vomiting
4. is subject to a high degree of first-pass metabolism
5. is used for administration of nitroglycerin

4.    The passage of drugs across the blood-brain barrier

1. is facilitated by a high degree of drug ionization
2. is most rapid for drugs with low lipid solubility
3. occurs more readily in the chemoreceptor trigger zone
4. is reduced by inflammation of the meninges
5. is rapid with aminoglycoside antibiotics