University of Illinois, Chicago

NURS 531

Chapter 5: Cell proliferation, apoptosis, repair and regeneration

MULTIPLE CHOICE

1)In the death receptor pathway, activation of tumor necrosis factor receptors causes the receptors to trimerize and complex an adapter protein, thereby leading to activation of

1. mitochondrial pathways
2. caspase-8
3. pro-apoptotic factor Bcl-2
4. a p53 protein
5. DNA transcription factors

2.    The activation of primitive stem cells so as to replace a damaged tissue is called

1. healing
2. repair
3. restoration
4. regeneration
5. rejuvenation

3.    Defective apoptosis may contribute to the development of

1. cancer
2. Alzheimer’s disease
3. myocardial infarction
4. aplastic anemia
5. stroke

4.    The activation of caspase-3 leads to

1. activation of transcription factors
2. inhibition of transcription factors
3. activation of the anti-apoptotic pathway
4. fragmentation of genomic DNA
5. stabilization of cell membranes

5.    Bortemozib causes accumulation of an apoptotic-promoter protein by inhibiting

1. mitochondrial DNA
2. suvivin
3. matrix metalolproteinases
4. pro-apoptotic Bcl-2
5. the proteasome