Niemann–Pick disease is a fatal lysosomal storage metabolic disorder caused by an autosomal recessive allele

Biology May 03, 2021

Niemann–Pick disease is a fatal lysosomal storage metabolic disorder caused by an autosomal recessive allele. A couple, both of whom are heterozygous for the allele, are wanting to start a family. They are hoping to have three children. What is the probability that if they have three children, none of them will have Niemann–Pick disease?

A. 1/4

B. 1/3

C. 2/3

D. 9/64

E. 27/64

Expert Solution

Answer:

E). 27/64

Explanation:

Pp x Pp ---Parents

	P	p
P	PP (normal)	Pp (normal)
p	Pp (normal)	pp (Neimann-pick disease)

Normal = ¾

Neimann-pick disease = ¼

The probability that the three children are normal = ¾ * ¾ * ¾ = 27/64

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