The enzyme telomerase consists of protein and an RNA containing a template sequence that directs the addition of an end sequence appropriate for the species

Biology Nov 19, 2020

The enzyme telomerase consists of protein and an RNA containing a template sequence that directs the addition of an end sequence appropriate for the species. Telomere sequences (TTGGGG) from the ciliated protozoan Tetrahymena were cloned onto the ends of a linear YAC, which was then transformed into yeast. The YAC survived as a linear piece of DNA but the YAC now had TGGTGG sequences at the very ends in addition to TTGGGG.