1)Unlike the monoamine transmitters discussed in previous chapters, there is no reuptake system for ACh itself

1)Unlike the monoamine transmitters discussed in previous chapters, there is no reuptake system for ACh itself. Describe the alternative mechanism that has evolved to help cholinergic neurons recycle/reutilize the transmitter. How do we know that this recycling process plays an important role in normal functioning of the nervous system?

2)List and discuss the various drugs that function as AChE inhibitors. In general, what is the effect of these drugs on cholinergic transmission? Include in your answer a consideration of the different consequences of peripheral versus central AChE inhibition and also the different consequences of reversible versus irreversible inhibition of the enzyme.