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1)What is known about the molecular mechanisms that underlie the development of tolerance to repeated cannabis exposure? 2)(a) Describe the symptoms of withdrawal from chronic cannabis use

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1)What is known about the molecular mechanisms that underlie the development of tolerance to repeated cannabis exposure?

2)(a) Describe the symptoms of withdrawal from chronic cannabis use. (b) How is cannabis withdrawal studied in experimental animal models?

3)Discuss the current treatments for cannabis use disorder, including new information on the potential efficacy of nabiximols as an adjunct therapy for reducing withdrawal symptoms.